Testing Options for Walsh Biotypes & Functional Mental Health

Walsh biotypes can be identified through symptoms alone, but laboratory testing provides clear biochemical confirmation and guides precise nutrient therapy.
WalshDoc offers all clinically relevant tests used in nutrient-based psychiatry, including the Comprehensive Biotype Panel, full methylation pathway analysis, and condition-specific functional labs.

These tests can be ordered individually or combined into panels depending on your symptoms and goals.

THE CORE TESTS

All biotype-focused care begins with the two most important labs:

1. Comprehensive Biotype Panel

(Most inclusive — best starting point)

Includes:

  • Whole Blood Histamine – methylation status

  • Homocysteine – methyl cycle stress

  • CBC – inflammation, nutrient patterns, lymphocyte shifts

  • Comprehensive Metabolic Panel – liver/kidney status, electrolyte balance

  • Vitamin D (25-OH)

  • Serum Copper

  • Serum Zinc

  • Ceruloplasmin

  • Copper:Zinc Ratio

Why it matters:
This panel identifies the major contributors to mood, anxiety, OCD, irritability, attention changes, stress intolerance, and fatigue.
It also sets the foundation for safe nutrient therapy, since copper imbalance must be treated BEFORE methylation support.

Recommended for:
✔ Anxiety
✔ OCD tendencies
✔ Depression & mood swings
✔ ADHD traits
✔ Fatigue/stress intolerance
✔ Postpartum symptoms

2. Methylation Pathway Panel (Doctor’s Data)

(Full metabolic view of methylation pathways)

Includes:

  • SAMe

  • SAH

  • SAM:SAH ratio

  • Methionine

  • Cystathionine

  • Cysteine

  • Homocysteine

  • Folate-related metabolites

Why it matters:
This test maps the entire methylation cycle, showing:

  • methylation efficiency

  • where bottlenecks occur

  • whether “undermethylation symptoms” are due to low SAM, high SAH, or oxidative stress

  • creatine demand

  • sulfur pathway stress

Recommended for:
✔ OCD
✔ Chronic fatigue
✔ Multi-system stress
✔ Complex depression/anxiety
✔ When methylation therapy is being considered

FOCUSED PANELS

These are chosen based on symptoms or as a first-step approach.

3. Copper/Zinc + Ceruloplasmin Panel

(Best first test before any methylation therapy)

Includes:

  • Copper

  • Zinc

  • Ceruloplasmin

  • Copper:Zinc ratio

Why it matters:
Copper overload is the most common cause of anxiety, agitation, overstimulation, panic, ADHD-like symptoms, postpartum symptoms, and emotional intensity.

This panel is often ordered first because for many patients:

➡ Stabilizing copper and zinc reduces 50–80% of symptoms,
and methylation treatment should not begin until copper is corrected.

4. Individual Biotype Tests

Order any test individually:

  • Whole blood histamine

  • Serum copper

  • Serum zinc

  • Ceruloplasmin

  • Homocysteine

  • Vitamin D

  • CBC

  • CMP

  • Urine pyrroles

These provide targeted insight before choosing nutrient therapy.

ADVANCED FUNCTIONAL TESTING

These tests address broader contributors to chronic symptoms, fatigue, brain fog, and immune imbalance.

5. Hashimoto’s Autoimmune Thyroid Panel

Includes:

  • TSH

  • Free T4

  • Free T3

  • Total T4
  • Total T3

  • Anti-TPO

  • Reverse T3

Useful for:
✔ Anxiety
✔ Fatigue
✔ Depression
✔ Brain fog
✔ Weight changes
✔ Temperature intolerance

6. CDSA Stool Analysis (with parasites)

Evaluates:

  • bacterial flora

  • yeast

  • parasites

  • digestion/absorption

  • short-chain fatty acids

  • inflammation (calprotectin, etc.)

Useful for:
✔ Dysbiosis
✔ Chronic inflammation
✔ Nutrient malabsorption
✔ Irritability, fatigue, slow recovery
✔ Toxic overload symptoms

7. Viral Panel (Coxsackie, CMV, EBV)

Measures active/reactivated viral stressors that amplify:

  • fatigue

  • irritability

  • neurological symptoms

  • anxiety under stress

  • autoimmune tendencies

8. Folate Receptor Antibody Testing

Identifies folate receptor blocking antibodies, associated with:

  • neurological symptoms

  • mood issues

  • sensory processing

  • poor methylation response

9. Genetic Testing (MTHFR, COMT)

(Optional and supportive, not diagnostic)

Used only to understand tendencies —
NOT to predict methylation status.

Clinical methylation is determined through:

✔ Whole blood histamine
✔ SAM/SAH
✔ Metabolic markers

10. Inflammation Markers

Can include:

  • ESR

  • CRP

  • Ferritin

  • LDH

  • Uric acid

  • ANA (as needed)

Supports evaluation of chronic immune activation and oxidative stress.

11. Nutrient Status Testing

Individual options:

  • B12 

  • Folate (serum or RBC)

  • RBC Magnesium

  • Gliadin antibodies

  • Methylmalonic acid (MMA)

12. Hair Mineral & Toxin Analysis

Helpful for:

  • heavy metals

  • chronic fatigue

  • neurotoxicity

  • oxidative stress biotypes

HOW TESTING IS USED IN YOUR PLAN

Step 1 — Identify your biotype

via free assessment + questionnaire

Step 2 — Order appropriate labs

receive requisition for Lab Corp, from Second Opinion Physician

Step 3 —Order Consultation with Dr Epstein

complete questionnaire, receive assessment report with supplement plan

Step 4 — Review with Dr. Epstein

 discuss report based on Walsh and functional frameworks

Step 5 — Begin targeted nutrient therapy

Copper balance → methylation support → oxidative repair → mitochondrial support

Begin Your Biotype Evaluation

Whether you're experiencing anxiety, OCD, postpartum symptoms, depression, ADHD traits, or chronic fatigue, testing allows for precise and targeted treatment.

➡️ Start your free biotype assessment